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Scientific Program
Wednesday, October 16, 2024
13:00-13:30
Registration
Research at ICGEB, ICESP and C2PO
Chair: Bryan Strauss, ICESP (Brazil)
Center for Translational Research in Oncology, a research hub within a total cancer care center
Roger Chammas, ICESP (Brazil)
13:30-13:45
13:45-14:00
The role of ICGEB in research, training and technology transfer in biotechnology
Luiz Zerbini, ICGEB (South Africa)
14:00 - 14:45
Receptor Tyrosine kinases: therapeutic targets in cancer development
Luiz Zerbini, ICGEB (South Africa)
HPV/mRNA vaccine
Chair: Laura Sichero, ICESP (Brazil)
14:45 - 15:30
mRNA Vaccines for the Treatment of HPV-Induced Tumors
Jamile Ramos Silva, Imunotera (Brazil)
15:30 - 16:00
Human Papillomavirus E7: Novel targets for therapeutic intervention
Lawrence Banks, ICGEB (Italy)
16:00 - 16:30
Coffee break (posters)
16:30 - 17:15
Therapeutic cell-based vaccines against tumors induced by HPV: experimental and clinical efficacy evidences
Luis Carlos Souza Ferreira, ICB-USP (Brazil)
17:15 - 18:00
Prophylaxis of tumors induced by HPV
Luisa Villa, ICESP (Brazil)
Thursday, October 17, 2024
CAR T/NK cells for cancer immunotherapy
Chair: Eduardo Magalhães Rego, ICESP (Brazil)
8:30 - 9:15
CAR-T cell initiatives at the Brazilian National Cancer Institute
Martin Bonamino#, INCA (Brazil)
9:15 - 10:00
Manufacturing Challenges in CAR-T/NK Therapies: Ribeirao Preto Experience
Virginia Picanço e Castro#, FMRP (Brazil)
10:00 - 10:45
Keynote lecture: Genome editing of T lymphocytes for cancer immunotherapy
Chiara Bonini#, HSR (Italy)
10:45 - 11:15
Coffee break (posters)
Bringing novel approaches into the fold
Chair: Bryan Strauss, ICESP (Brazil)
Regulatory aspects of advanced therapies in Brazil
Renata Parca#, ANVISA (Brazil)
Keynote lecture: Oncolytic viruses for Pediatric Brain Tumors; From the Bench to the Bedside
Marta Alonso#, Navarra University Clinic (Spain)
Lunch (posters)
To infinity and beyond: IncuCyte Applications
Chair: Fernanda Antunes, ICESP (Brazil)
11:15 - 12:00
12:00 - 12:45
12:45 - 13:45
13:45 - 14:15
14:15 - 15:15
Leticia Queiroz da Silva, PhD#
Oral Abstracts: Session
Chair: Tharcisio Citrangulo Tortelli Junior, ICESP (Brazil)
Optical and electrochemical diagnosis using an epigenetic biomarker of breast cancer
Marlone Love Tchouptang Njiyip et al (Camaroon/Brazil)
WT1-5 rotavirus infects and induces death of tumor cells in vitro and in vivo
Haceneth Shantall Prieto Rodríguez et al (Colombia)
Development of a platform for gamma-delta T cell expansion and evaluation of cytotoxicity against tumor cells
Mateus da Silva Matias Antunes et al (Brazil)
TCR-depleted anti-GD2 ‘universal’ CAR-T allogeneic product exerts antitumoral activity against glioblastoma cells in vitro
Karolina Santos Esteves et al (Brazil)
15:15 – 15:45
Co-Expression of cJUN Enhances CRISPR Knock-In anti-B7H3 CAR T-cell Function for Small Cell Lung Cancer Treatment
Hyatt Balke-Want, MaxCyte (Germany)#
Chair: Fernanda Antunes, ICESP (Brazil)
15:45 - 16:15
Coffee break (posters)
Oncolytic approaches for cancer immunotherapy
Chair: Kirill Afonin, UNCC (USA)
16:15 - 17:00
Switching the balance between immune tolerance and surveillance to enhance antitumor response
Marcio C Bajgelman, LNBio (Brazil)
17:00 – 17:45
The difficult path to the clinic of a tumor stroma-targeted, TME-responsive, oncolytic virus
Osvaldo Podhajcer#, Instituto Leloir (Argentina)
17:45 - 18:30
Oncolysis in response to gene transfer
Bryan Strauss, ICESP (Brazil)
Friday, October 18, 2024
Non-coding RNA in cancer theranostics
Chair: Luciana Andrade, ICESP (Brazil)
8:30 - 9:15
Molecular pathway of radioiodine as a theranostic in thyroid cancer
Edna Teruko Kimura, ICB-USP (Brazil)
9:15 - 10:00
microRNAs associated with metastasis
Patricia Pintor dos Reis, UNESP (Brazil)
10:00 - 10:45
Keynote lecture: Living in the World of RNA Medicine
Muthiah Manoharan, Alnylam Pharmaceuticals, Cambridge, MA (USA)
10:45 - 11:15
Coffee break (posters)
Dynamic platforms for cancer therapy and diagnosis:
Chair: Renata Saito, ICESP (Brazil)
11:15 - 12:00
Nanodesign of Nucleic Acids Nanoparticles for Biomedical Applications
Kirill Afonin, UNCC (USA)
12:00 - 12:45
Immunological Properties of Nanocarriers and Nanoparticle-formulated Products: Lessons Learned from Two Decades of Preclinical Characterization at the Nanotechnology Characterization Lab
Marina Dobrovolskaia#, NIH (USA)
12:45 - 13:45
Lunch (posters)
13:45 – 14:00
Established Protocols for MSI Testing and the Clinical Importance of the MSI-H Biomarker
Chair: Fernanda Antunes, ICESP (Brazil)
14:00- 15:00
Oral Abstracts: Session II
Chair: Alexis Murillo Carrasco, ICESP (Brazil)
Cell membrane-functionalized nanoparticles containing imatinib for chronic myeloid leukemia therapy
Flávia Langellotti Silva et al (Brazil)
Enhancing Raman spectroscopy for improved characterization of extracellular vesicles in cancer biology
Marco Lazaro de Sousa Batista et al (Brazil)
Tailoring Amphiphilic Nanocarriers from Low Molecular Weight Chitosan for Effective Gene Therapy
Gabriel José De Carli et al (Brazil)
Down-modulation of MHC-I in tumor cells by bacterial RNA: a possible therapeutic strategy
Agustina Serafino et al (Argentina)
15:00 – 15:30
Safeguard Commercialization- Manage Raw Materials and Dual Sourcing Expectation
Chair: Fernanda Antunes, ICESP (Brazil)
15:30 - 16:00
Coffee break (posters)
Mayra Mancia MCTM (MS), MBA#
Eduardo Leal Rodrigues - Coordinator Scientist Promega
Dynamic platforms for cancer therapy and diagnosis: II
Chair: Andreia Otake, ICESP (Brazil)
16:00 – 16:45
Autonomous Nucleic Acid Nanoparticles Engineered to Operate in Living Cells
Afonin Kirill, UNCC (USA)
16:45 – 17:30
Targeting mechanisms of cancer treatment resistance with miRNAs and nanostructures RNAs
Roger Chammas, ICESP (Brazil)
17:30 – 18:15
Keynote lecture: NanoComputing Agents: Hacking Cellular Behavior
Nikolay Dokholyan, Penn State College of Medicine (USA)
Saturday, October 19, 2024
Hitting the target using nanobiosystems
Chair: Roger Chammas, ICESP (Brazil)
8:30 – 9:15
Introduction to and use of extracellular vesicles
Luciana Andrade, ICESP (Brazil)
9:15 - 10:00
Anticoagulant RNA-DNA biomolecular platform for the management of cancer-associated thrombosis
Renata de Freitas Saito, ICESP (Brazil)
10:00 – 10:30
Accelerating nucleic acid therapeutics | The growing potential of RNA-LNP therapeutics for cell therapy
Chair: Fernanda Antunes, ICESP (Brazil)
10:30 - 11:00
Coffee break (posters)
11:00 - 11:45
The Nanomedicine Revolution: Advances in Diagnosis and Therapy
Valtencir Zucolotto, USP IFSC (Brazil)
11:45 - 12:30
Keynote lecture: Bioengineering extracellular vesicles as therapeutic vehicles
Xandra Breakefield#, Harvard/Mass Gen (USA)
12:30 - 12:45
Closing Ceremony and Awards Presentation
12:45 - 14:00
Closing event reception
14:00 - 18:00
Laboratory workshops
Mariana Oliveira, PhD - Field Application Specialist, Cytiva
*Note: All lecture titles are provisionary and will be updated as plans are finalized. TBD, to be determined.
#Note: This presentation will be made remotely.Coffee breaks are included with registration. Drinks/snacks will be provided.Lunches are included with registration. Meals, including vegan and gluten free options, will be provided.